公开(公告)号：US12109219B2

公开(公告)日：2024-10-08

申请号：US16849216

申请日：2020-04-15

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: A61K31/675 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/497 ,  A61K45/06

CPC classification number: A61K31/675 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/497 ,  A61K45/06 ,  A61K31/416 ,  A61K2300/00

Abstract: Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

公开(公告)号：US11771695B2

公开(公告)日：2023-10-03

申请号：US17478274

申请日：2021-09-17

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: A61K31/497 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/6558 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/675 ,  A61K45/06 ,  A61K31/13 ,  A61K31/485

CPC classification number: A61K31/497 ,  A61K31/13 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/675 ,  A61K45/06 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/65583

Abstract: Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

公开(公告)号：US20210060040A1

公开(公告)日：2021-03-04

申请号：US16849216

申请日：2020-04-15

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: A61K31/675 ,  A61K31/416 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/497

Abstract: Provided are certain methods useful in the treatment of cancer comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

公开(公告)号：US20180354907A1

公开(公告)日：2018-12-13

申请号：US15912700

申请日：2018-03-06

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Robert M. Jones ,  Sangdon Han ,  Lars Thoresen ,  Jae-Kyu Jung ,  Sonja Strah-Pleynet ,  Xiuwen Zhu ,  Yifeng Xiong ,  Dawei Yue

IPC: C07D231/54 ,  C07D403/04 ,  C07D413/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07F9/6558 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D231/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07F9/65583

Abstract: The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease.

公开(公告)号：US20160271127A1

公开(公告)日：2016-09-22

申请号：US14956586

申请日：2015-12-02

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: A61K31/497 ,  A61K31/675 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/416

CPC classification number: A61K31/497 ,  A61K31/13 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/675 ,  A61K45/06 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/65583

Abstract: Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

公开(公告)号：US20220306586A1

公开(公告)日：2022-09-29

申请号：US17520952

申请日：2021-11-08

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Robert M. Jones ,  Sangdon Han ,  Lars Thoresen ,  Jae-Kyu Jung ,  Sonja Strah-Pleynet ,  Xiuwen Zhu ,  Yifeng Xiong ,  Dawei Yue

IPC: C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/6558 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease.

公开(公告)号：US09867822B2

公开(公告)日：2018-01-16

申请号：US15279576

申请日：2016-09-29

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: C07D403/04 ,  C07D231/54 ,  C07D401/04 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/416 ,  C07D401/14 ,  C07D405/14 ,  C07F9/6558 ,  A61K31/675 ,  A61K45/06 ,  A61K31/13 ,  A61K31/485

CPC classification number: A61K31/497 ,  A61K31/13 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/675 ,  A61K45/06 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/65583

Abstract: Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

公开(公告)号：US09492447B2

公开(公告)日：2016-11-15

申请号：US14956586

申请日：2015-12-02

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: C07D401/04 ,  C07D403/04 ,  C07D231/54 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/416 ,  A61K45/06 ,  A61K31/675

CPC classification number: A61K31/497 ,  A61K31/13 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/675 ,  A61K45/06 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/65583

Abstract: Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;

公开(公告)号：US11746091B2

公开(公告)日：2023-09-05

申请号：US17024752

申请日：2020-09-18

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Robert M. Jones ,  Sangdon Han ,  Lars Thoresen ,  Jae-Kyu Jung ,  Sonja Strah-Pleynet ,  Xiuwen Zhu ,  Yifeng Xiong ,  Dawei Yue

IPC: C07D231/54 ,  C07D401/04 ,  C07D403/04 ,  C07F9/6558 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D231/54 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07F9/65583

Abstract: The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease.

公开(公告)号：US20220241274A1

公开(公告)日：2022-08-04

申请号：US17478274

申请日：2021-09-17

Applicant: Arena Pharmaceuticals, Inc.

Inventor： Jayant Thatte ,  Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Jae-Kyu Jung ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter ,  Sonja Strah-Pleynet ,  Lars Thoresen ,  Yifeng Xiong ,  Dawei Yue ,  Xiuwen Zhu

IPC: A61K31/497 ,  C07D231/54 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07F9/6558 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/675 ,  A61K45/06 ,  A61K31/13 ,  A61K31/485

Abstract: Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor;