专利检索 ap:("Antheia, Inc.") AND inv:"Christina D. SMOLKE" 第 1 页

1.

发明公开
METHODS OF PRODUCING MORPHINAN ALKALOIDS AND DERIVATIVES 审中-公开

公开(公告)号：US20240209403A1

公开(公告)日：2024-06-27

申请号：US18511394

申请日：2023-11-16

申请人： Antheia, Inc.

发明人： Christina D. SMOLKE , Isis TRENCHARD , Kristy M. HAWKINS , Catherine THODEY

IPC分类号： C12P17/12 , C12N9/88 , C12N9/90 , C12N15/52

CPC分类号： C12P17/12 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y402/99

摘要： A method of producing promorphinan, morphinan, nal-opioid, and nor-opioid alkaloid products through the increased conversion of a promorphinan alkaloid to a morphinan alkaloid. The method comprises contacting the promorphinan alkaloid with at least one enzyme. Contacting the promorphinan alkaloid with the at least one enzyme converts the promorphinan alkaloid to a morphinan alkaloid.

2.

发明公开
METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES 审中-公开

公开(公告)号：US20240102061A1

公开(公告)日：2024-03-28

申请号：US18253585

申请日：2021-11-18

申请人： ANTHEIA, INC.

发明人： Christina D. SMOLKE , Catherine THODLEY , KRISTY M. HAWKINS , Kenneth TAKEOKA , Douglas HANSEN

IPC分类号： C12P17/12 , C12N9/88 , C12N15/52

CPC分类号： C12P17/12 , C12N9/88 , C12N15/52 , C12Y402/01078

摘要： Methods and engineered cells are provided for increasing activity of a norcoclaurine synthase in a microbial cell. The method comprises, within the engineered microbial cell, contacting an engineered norcoclaurine synthase with a substrate, wherein contacting the substrate with the engineered norcoclaurine synthase increases conversion, within the engineered microbial cell, in comparison to a non-engineered norcoclaurine synthase.