公开(公告)号：US10508149B2

公开(公告)日：2019-12-17

申请号：US15563924

申请日：2016-04-01

Applicant: AnaptysBio, Inc.

Inventor： Marilyn Kehry ,  David J. King ,  Jean Da Silva Correia

IPC: C07K16/28 ,  A61P37/00 ,  A61P35/00 ,  A61K39/00

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the T Cell Immunoglobulin and Mucin Protein-3 (HM-3). The invention provides a TIM-3-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the TIM-3-binding agent to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.

公开(公告)号：US11352427B2

公开(公告)日：2022-06-07

申请号：US16655939

申请日：2019-10-17

Applicant: AnaptysBio, Inc.

Inventor： Marilyn Kehry ,  David J. King ,  Jean Da Silva Correia

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  A61P37/00 ,  A61P35/00 ,  A61K39/00

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the T Cell Immunoglobulin and Mucin Protein-3 (TIM-3). The invention provides a TIM-3-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the TIM-3-binding agent to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.