公开(公告)号：US20130345432A1

公开(公告)日：2013-12-26

申请号：US13955343

申请日：2013-07-31

Applicant: Amgen Inc.

Inventor： Seb CAILLE ,  Sheng CUI ,  Xiang WANG ,  Margaret FAUL

IPC: C07D277/54

CPC classification number: C07D277/54

Abstract: The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts.

Abstract translation: 本发明提供两种合成取代的氨基噻唑酮化合物作为11型11-β-羟基类固醇脱氢酶抑制剂的方法。该方法允许所需化合物的立体选择性合成而不使用化学计量的手性催化剂。