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公开(公告)号：US20210155710A1
公开(公告)日：2021-05-27
申请号：US16972298
申请日：2019-06-05
Applicant: Amgen Inc.
Inventor： Scott KUHNS , Junyan SHU , Qingchun ZHANG
Abstract: Provided herein are methods of modulating Antibody Dependent Cellular Phagocytosis (ADCP) activity of an antibody composition. In exemplary embodiments, the method comprises modulating the amount of (a) galactosylated glycans of the antibody, (b) afucosylated glycans of the antibody, (c) high mannose glycans of the antibody, or (d) a combination thereof, to modulate ADCP activity of the antibody, as further described herein.
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