公开(公告)号：US11965029B2

公开(公告)日：2024-04-23

申请号：US17339301

申请日：2021-06-04

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/28 ,  C07K16/24 ,  A61K39/00 ,  C12N15/11

CPC classification number: C07K16/2866 ,  C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US09982054B2

公开(公告)日：2018-05-29

申请号：US15178652

申请日：2016-06-10

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/28 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US11059895B2

公开(公告)日：2021-07-13

申请号：US16242278

申请日：2019-01-08

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/28 ,  C07K16/24 ,  A61K39/00 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and derivatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US10227414B2

公开(公告)日：2019-03-12

申请号：US15601868

申请日：2017-05-22

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: A61K39/00 ,  C07K16/24 ,  C07K16/28

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

公开(公告)号：US09382318B2

公开(公告)日：2016-07-05

申请号：US13897096

申请日：2013-05-17

Applicant: Amgen Inc.

Inventor： Dirk E. Smith ,  Ian Foltz ,  Chadwick T. King ,  Ai Ching Lim ,  Rutilio Clark ,  Michael R. Comeau ,  Randal R. Ketchem ,  Donghui Shi ,  Xiaoshan Min ,  Zhulun Wang

IPC: C07K16/24 ,  C12N15/11 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。