公开(公告)号：US20230257722A1

公开(公告)日：2023-08-17

申请号：US17253863

申请日：2019-06-26

申请人： Altius Institute for Biomedical Sciences

发明人： John A. Stamatoyannopoulos ,  Fyodor Urnov ,  Jocelynn Pearl ,  Sean Thomas

IPC分类号： C12N9/22 ,  C12N15/52 ,  C07K19/00

CPC分类号： C12N9/22 ,  C07K19/00 ,  C12N15/52 ,  C07K2319/81

摘要： DNA cleaving enzymes are disclosed. The DNA cleaving enzymes are fused to a heterologous DNA binding domain that is designed to bind to a target nucleic acid sequence. Nucleic acids and expression cassettes encoding the DNA cleaving enzymes are also provided. Methods for genome editing using the DNA cleaving enzymes, fusion proteins, and compositions thereof are disclosed herein.