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公开(公告)号：US20140256658A1
公开(公告)日：2014-09-11
申请号：US14199310
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
IPC分类号： A61K47/48
CPC分类号： A61K9/0048 , A61K47/55 , A61K47/554 , A61K47/64 , C07K7/645
摘要： The present invention describes antibiotic conjugates. These single drug entities are formed connecting one antibiotic with another antibiotic. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
摘要翻译： 本发明描述了抗生素缀合物。 这些单一药物实体形成连接一个抗生素与另一种抗生素。 当局部应用于眼睛时，缀合物杂交体将进行酶促和/或水解裂解以释放各种药物。
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公开(公告)号：US20140256694A1
公开(公告)日：2014-09-11
申请号：US14199212
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
CPC分类号： A61K9/0048 , A61K47/55 , A61K47/554 , A61K47/64 , C07K7/645
摘要： The present invention describes steroid antibiotic conjugates. These single drug entities are formed connecting a steroid moiety and two same antibiotics moieties, or a steroid moiety and two different antibiotics moieties. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
摘要翻译： 本发明描述了类固醇抗生素缀合物。 这些单一药物实体形成连接类固醇部分和两个相同的抗生素部分，或类固醇部分和两个不同的抗生素部分。 当局部应用于眼睛时，缀合物杂交体将进行酶促和/或水解裂解以释放各种药物。
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公开(公告)号：US20140256612A1
公开(公告)日：2014-09-11
申请号：US14198939
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
CPC分类号： A61K47/48115 , A61K9/0048 , A61K47/552 , A61K47/554 , C07D215/56 , C07D401/04 , C07D405/12 , C07D471/04 , C07D498/06
摘要： The present invention describes novel single drug entities, formed by direct linkage of an antibiotic to a steroidal drug. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs. The antibiotic is coupled directly to the steroid drug.
摘要翻译： 本发明描述了通过将抗生素直接连接到甾族药物而形成的新型单一药物实体。 当局部施用于眼睛时，缀合物将进行酶促和/或水解切割以释放各种药物。 抗生素直接与类固醇药物结合。
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公开(公告)号：US20140256666A1
公开(公告)日：2014-09-11
申请号：US14198881
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
IPC分类号： A61K47/48
CPC分类号： A61K47/552 , C07D309/14 , C07D405/14 , C07D487/04 , C07H15/234
摘要： The present invention describes single drug entities, formed by connecting an antibiotic moiety via a linker with a non-steroidal anti-inflammatory drug (NSAID) moiety. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual antibiotic and NSAID drug.
摘要翻译： 本发明描述了通过将抗生素部分经由接头与非甾体抗炎药（NSAID）部分连接形成的单一药物实体。 在局部施用于眼睛时，缀合物杂交体将进行酶促和/或水解切割以释放单独的抗生素和NSAID药物。
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公开(公告)号：US20140256660A1
公开(公告)日：2014-09-11
申请号：US14199101
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
CPC分类号： A61K9/0048 , A61K47/552 , A61K47/554 , C07J41/005 , C07J43/003
摘要： The present invention describes novel single drug entities, formed by the linkage of an antibiotic with a steroidal drug via a linker. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
摘要翻译： 本发明描述了通过接头将抗生素与甾体药物连接形成的新型单一药物实体。 当局部施用于眼睛时，缀合物将进行酶促和/或水解切割以释放各种药物。
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公开(公告)号：US20140256696A1
公开(公告)日：2014-09-11
申请号：US14199514
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
CPC分类号： A61K9/0048 , A61K47/55 , A61K47/554 , A61K47/64 , C07K7/645
摘要： The present invention describes steroid conjugates. These single drug entities are formed by connecting two or more steroids via a linker. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual steroid drugs.
摘要翻译： 本发明描述了类固醇缀合物。 这些单一药物实体通过连接物连接两个或多个类固醇形成。 在局部施用于眼睛时，缀合物杂交体将进行酶促和/或水解切割以释放单独的类固醇药物。
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公开(公告)号：US20140256651A1
公开(公告)日：2014-09-11
申请号：US14199432
申请日：2014-03-06
申请人： Allergan, Inc.
发明人： Santosh C. Sinha , Ken Chow , LIMING WANG , MICHAEL E. GARST , MAYSSA ATTAR , BRANDON D. SWIFT
CPC分类号： A61K47/48115 , A61K9/0048 , A61K47/481 , A61K47/48123 , A61K47/48246 , A61K47/55 , A61K47/554 , A61K47/64 , C07K7/645
摘要： The present invention describes Cyclosporine A/steroid hybrid analogs. These single drug entities are formed by connecting a steroid with Cyclosporine A. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
摘要翻译： 本发明描述了环孢菌素A /类固醇混合物类似物。 这些单一药物实体通过将类固醇与环孢霉素A连接形成。在局部施用于眼睛时，缀合物杂交体将进行酶促和/或水解切割以释放各种药物。
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