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    PREPARATION OF INJECTABLE SUSPENSIONS HAVING IMPROVED INJECTABILITY
    8.
    发明申请
    PREPARATION OF INJECTABLE SUSPENSIONS HAVING IMPROVED INJECTABILITY 审中-公开
    具有改进注意力的注射式悬架的制备

    公开(公告)号：US20140193507A1

    公开(公告)日：2014-07-10

    申请号：US14085051

    申请日：2013-11-20

    申请人： Alkermes Pharma Ireland Limited ,  Alkermes Controlled Therapeutics, Inc.

    发明人： J. Michael Ramstack ,  M. Gary I. Riley ,  Stephen E. Zale ,  Joyce M. Hotz ,  Olufunmi L. Johnson

    IPC分类号： A61K47/34 ,  A61K9/00

    CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K31/505 ,  A61K47/26 ,  A61K47/38

    摘要： Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. The injectable compositions can be made by mixing dry microparticles with an aqueous injection vehicle to form a suspension, and then mixing the suspension with a viscosity enhancing agent to increase the viscosity of the fluid phase of the suspension to the desired level for improved injectability.

    摘要翻译： 具有改进的注射性的可注射组合物。 可注射组合物包括悬浮在20摄氏度粘度至少为20cp的含水注射用载体中的微粒。构成悬浮液相的注射载体的增加的粘度显着降低体内注射性失败。 可注射组合物可以通过将干燥微粒与水性注射载体混合以形成悬浮液，然后将悬浮液与粘度增强剂混合以将悬浮液的流体相的粘度增加至所需水平以改善注射性，从而制备。