公开(公告)号：US20170267751A1

公开(公告)日：2017-09-21

申请号：US15476644

申请日：2017-03-31

Applicant: Alexion Pharmaceuticals, Inc.

Inventor： Russell P. ROTHER ,  Hao WANG ,  Zhen ZHONG

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505

Abstract: Methods of prolonging survival of allotransplanted cells, tissues or organs are presented. These methods are directed to administering to the allotransplant recipient an inhibitor of complement activity together with one or more immunosuppressants. The inhibitor of complement activity is administered chronically. These methods have been determined to aid in preventing chronic rejection of allografts. These methods can additionally be used in cases in which the recipient has been presensitized to the allograft or in which there is an ABO mismatch between the allograft and the recipient.