公开(公告)号：US07767090B2

公开(公告)日：2010-08-03

申请号：US11604458

申请日：2006-11-27

申请人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

发明人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： G01N30/52 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

摘要翻译： 本发明提供了一种用于保持色谱柱内的介质床的压实并因此提高效率的自动化系统和方法。 在优选实施例中，调节组件滑动地接合在柱的一端内，使得其可以沿柱的长轴移动。 当空闲时，施加在该端的力等于介质上的压缩。 当柱正在积极处理色谱流体时，该施加的力可以表示为介质上的压缩和被处理的流体的力之和。 分别使用称重传感器和压力传感器监测该总力和流体压力。 然后基于这些测量计算在介质床上操作的压缩力，并与最佳值进行比较。 响应于测量的压缩力的变化，调节组件在柱内的位置随后被修改。

公开(公告)号：US20090014389A1

公开(公告)日：2009-01-15

申请号：US12283016

申请日：2008-09-09

申请人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

发明人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

IPC分类号： B01D21/34 ,  B01D15/08

CPC分类号： B01D15/206 ,  B01D15/20 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.

摘要翻译： 本发明提供一种用于填充色谱柱的自动化系统和方法。 在一个实施例中，系统首先确定列中存在的媒体的类型，并且使用该信息来生成用于打包特定媒体类型的自动化过程。 在第二实施例中，媒体类型是系统已知的，例如通过来自操作者的输入。 然后，系统以与第一实施例中相同的方式使用该信息来生成用于打包特定媒体类型的自动化过程。 最后，在第三实施例中，例如通过来自操作者的输入，诸如列高度和压缩率的参数对于系统是已知的。 然后系统按照这些提供的参数包装色谱柱。

公开(公告)号：US08114295B2

公开(公告)日：2012-02-14

申请号：US12283016

申请日：2008-09-09

申请人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

发明人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： B01D15/206 ,  B01D15/20 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.

摘要翻译： 本发明提供一种用于填充色谱柱的自动化系统和方法。 在一个实施例中，系统首先确定列中存在的媒体的类型，并且使用该信息来生成用于打包特定媒体类型的自动化过程。 在第二实施例中，媒体类型是系统已知的，例如通过来自操作者的输入。 然后，系统以与第一实施例相同的方式使用该信息来生成用于打包特定媒体类型的自动化过程。 最后，在第三实施例中，例如通过来自操作者的输入，诸如列高度和压缩率的参数对于系统是已知的。 然后系统按照这些提供的参数包装色谱柱。

公开(公告)号：US20100256925A1

公开(公告)日：2010-10-07

申请号：US12818287

申请日：2010-06-18

申请人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

发明人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC分类号： G06F19/00 ,  G01N30/00

CPC分类号： G01N30/52 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

摘要翻译： 本发明提供了一种用于保持色谱柱内的介质床的压实并因此提高效率的自动化系统和方法。 在优选实施例中，调节组件滑动地接合在柱的一端内，使得其可以沿柱的长轴移动。 当空闲时，施加在该端的力等于介质上的压缩。 当柱正在积极处理色谱流体时，该施加的力可以表示为介质上的压缩和被处理的流体的力之和。 分别使用称重传感器和压力传感器监测该总力和流体压力。 然后基于这些测量计算在介质床上操作的压缩力，并与最佳值进行比较。 响应于测量的压缩力的变化，调节组件在柱内的位置随后被修改。

公开(公告)号：US07435350B2

公开(公告)日：2008-10-14

申请号：US11098505

申请日：2005-04-04

申请人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

发明人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： B01D15/206 ,  B01D15/20 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.

摘要翻译： 本发明提供一种用于填充色谱柱的自动化系统和方法。 在一个实施例中，系统首先确定列中存在的媒体的类型，并且使用该信息来生成用于打包特定媒体类型的自动化过程。 在第二实施例中，媒体类型是系统已知的，例如通过来自操作者的输入。 然后，系统以与第一实施例中相同的方式使用该信息来生成用于打包特定媒体类型的自动化过程。 最后，在第三实施例中，例如通过来自操作者的输入，诸如列高度和压缩率的参数对于系统是已知的。 然后系统按照这些提供的参数包装色谱柱。

公开(公告)号：US07238282B2

公开(公告)日：2007-07-03

申请号：US11072081

申请日：2005-03-04

申请人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

发明人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： G01N30/52 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

公开(公告)号：US20060196832A1

公开(公告)日：2006-09-07

申请号：US11072081

申请日：2005-03-04

申请人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

发明人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： G01N30/52 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

公开(公告)号：US08591742B2

公开(公告)日：2013-11-26

申请号：US12818287

申请日：2010-06-18

申请人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

发明人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： G01N30/52 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

摘要翻译： 本发明提供了一种用于保持色谱柱内的介质床的压实并因此提高效率的自动化系统和方法。 在优选实施例中，调节组件滑动地接合在柱的一端内，使得其可以沿柱的长轴移动。 当空闲时，施加在该端的力等于介质上的压缩。 当柱正在积极处理色谱流体时，该施加的力可以表示为介质上的压缩和被处理的流体的力之和。 分别使用称重传感器和压力传感器监测该总力和流体压力。 然后基于这些测量计算在介质床上操作的压缩力，并与最佳值进行比较。 响应于测量的压缩力的变化，调节组件在柱内的位置随后被修改。

公开(公告)号：US20070262021A1

公开(公告)日：2007-11-15

申请号：US11604458

申请日：2006-11-27

申请人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

发明人： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： G01N30/52 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

摘要翻译： 本发明提供了一种用于保持色谱柱内的介质床的压实并因此提高效率的自动化系统和方法。 在优选实施例中，调节组件滑动地接合在柱的一端内，使得其可以沿柱的长轴移动。 当空闲时，施加在该端的力等于介质上的压缩。 当柱正在积极处理色谱流体时，该施加的力可以表示为介质上的压缩和被处理的流体的力之和。 分别使用称重传感器和压力传感器监测该总力和流体压力。 然后基于这些测量计算在介质床上操作的压缩力，并与最佳值进行比较。 响应于测量的压缩力的变化，调节组件在柱内的位置随后被修改。

公开(公告)号：US20060219616A1

公开(公告)日：2006-10-05

申请号：US11098505

申请日：2005-04-04

申请人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

发明人： Aaron Noyes ,  Jeremy Perreault ,  Mark Carroll

IPC分类号： B01D15/08

CPC分类号： B01D15/206 ,  B01D15/20 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.