公开(公告)号：US10369130B2

公开(公告)日：2019-08-06

申请号：US15534874

申请日：2015-12-11

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.

Inventor： Rosella Ombrato ,  Barbara Garofalo ,  Giorgina Mangano ,  Alessandra Capezzone De Joannon ,  Gaia Corso ,  Gabriele Magaro′ ,  Guido Furlotti ,  Tommaso Iacoangeli

IPC: A61K31/4725 ,  A61P31/04 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  A61K31/33 ,  C07D405/14 ,  C07D413/14 ,  C07D405/12 ,  C07D407/14 ,  C07D409/14

Abstract: The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

公开(公告)号：US10221144B2

公开(公告)日：2019-03-05

申请号：US15533594

申请日：2015-12-14

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.

Inventor： Rosella Ombrato ,  Barbara Garofalo ,  Giorgina Mangano ,  Alessandra Capezzone De Joannon ,  Gaia Corso ,  Claudia Cavarischia ,  Guido Furlotti ,  Tommaso Iacoangeli

IPC: C07C241/04 ,  C07D241/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D497/04 ,  A61K31/496 ,  C07D211/94 ,  C07D211/96

Abstract: The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

公开(公告)号：US10005730B2

公开(公告)日：2018-06-26

申请号：US14969454

申请日：2015-12-15

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F S.p.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Isabella Coletta ,  Patrizia Dragone ,  Guido Furlotti ,  Barbara Garofalo ,  Angelo Guglielmotti ,  Giorgina Mangano ,  Caterina Maugeri

IPC: C07D209/88

CPC classification number: C07D209/88

Abstract: The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.

公开(公告)号：US09655906B2

公开(公告)日：2017-05-23

申请号：US14803384

申请日：2015-07-20

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F S.p.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Guido Furlotti ,  Beatrice Garrone ,  Gabriele Magaro ,  Giorgina Mangano

IPC: A61K31/4985 ,  C07D487/04 ,  A61K31/551

CPC classification number: A61K31/551 ,  A61K31/4985 ,  C07D487/04

Abstract: Tricyclic indazole compound and its pharmaceutically acceptable salts of acid addition, use thereof, method and intermediates for preparing them, and a pharmaceutical composition containing them.The tricyclic indazole compound has the following general formula (I): in which R1, R2, L1, L2, X1, X2, X3, X4, X5, Y, W, m, and n have the meanings stated in the description.

公开(公告)号：US10160746B2

公开(公告)日：2018-12-25

申请号：US15439172

申请日：2017-02-22

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Patrizia Dragone ,  Guido Furlotti ,  Caterina Maugeri ,  Rosella Ombrato ,  Francesca Mancini

IPC: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506

Abstract: The present invention relates to the 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3β-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; (viii) epilepsies; and (ix) neuropathic pain.

公开(公告)号：US09700551B2

公开(公告)日：2017-07-11

申请号：US14825261

申请日：2015-08-13

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Barbara Garofalo ,  Guido Furlotti ,  Gabriele Magaro' ,  Rosella Ombrato ,  Francesca Mancini

IPC: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D417/14

CPC classification number: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to the new use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3β-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; and (viii) epilepsies.

公开(公告)号：US20170157121A1

公开(公告)日：2017-06-08

申请号：US15439172

申请日：2017-02-22

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

Inventor： Maria Alessandra ALISI ,  Nicola Cazzolla ,  Patrizia Dragone ,  Guido Furlotti ,  Caterina Maugeri ,  Rosella Ombrato ,  Francesca Mancini

IPC: A61K31/506 ,  A61K31/4545 ,  A61K31/454

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to the 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3β-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; (viii) epilepsies; and (ix) neuropathic pain.

公开(公告)号：US09611249B2

公开(公告)日：2017-04-04

申请号：US14373100

申请日：2013-02-07

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Patrizia Dragone ,  Guido Furlotti ,  Caterina Maugeri ,  Rosella Ombrato ,  Francesca Mancini

IPC: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to the 1H-indazole-3-carboxamide compounds having the following general formula (I) as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3p-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; (viii) epilepsies; and (ix) neuropathic pain.

公开(公告)号：US20140378455A1

公开(公告)日：2014-12-25

申请号：US14373393

申请日：2013-02-08

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Barbara Garofalo ,  Guido Furlotti ,  Gabriele Magaro' ,  Rosella Ombrato ,  Francesca Mancini

IPC: C07D417/14 ,  C07D405/14 ,  C07D401/12 ,  C07D413/14

CPC classification number: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors. The present invention relates to the 1H-indazole-3-carboxamide compounds for use as glycogen synthase kinase 3 beta (GSK-33) inhibitors and to their use in the treatment of GSK-3p-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; and (viii) epilepsies.

Abstract translation: 1H-吲唑-3-甲酰胺化合物作为糖原合酶激酶3β抑制剂。 本发明涉及用作糖原合酶激酶3β（GSK-33）抑制剂的1H-吲唑-3-甲酰胺化合物及其在治疗GSK-3p相关病症中的用途，例如（i ）胰岛素抵抗障碍; （ii）神经变性疾病; （iii）情绪障碍; （iv）精神分裂症; （v）癌症; （vi）炎症，（vii）物质滥用障碍; 和（viii）癫痫。

公开(公告)号：US09163013B2

公开(公告)日：2015-10-20

申请号：US14373393

申请日：2013-02-08

Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

Inventor： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Barbara Garofalo ,  Guido Furlotti ,  Gabriele Magaro′ ,  Rosella Ombrato ,  Francesca Mancini

IPC: A61K31/5377 ,  A61K31/454 ,  C07D413/14 ,  C07D211/68 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D401/12

CPC classification number: A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors. The present invention relates to the 1H-indazole-3-carboxamide compounds for use as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3β-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; and (viii) epilepsies.

Abstract translation: 1H-吲唑-3-甲酰胺化合物作为糖原合酶激酶3β抑制剂。 本发明涉及用作糖原合酶激酶3β（GSK-3＆bgr））抑制剂的1H-吲唑-3-甲酰胺化合物，以及它们在治疗GSK-3和相关病症中的用途，例如， （i）胰岛素抵抗障碍; （ii）神经变性疾病; （iii）情绪障碍; （四）精神分裂症; （v）癌症; （vi）炎症，（vii）物质滥用障碍; 和（viii）癫痫。