公开(公告)号：US20220402873A1

公开(公告)日：2022-12-22

申请号：US17761830

申请日：2020-09-21

申请人： AUTOTAC INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Yong Tae KWON ,  Chang Hoon JI ,  Hyun Tae KIM ,  Jeong Eun NA ,  Hee Yeon KIM ,  Min Ju LEE

IPC分类号： C07D213/64 ,  C07D213/69 ,  C07D239/34 ,  C07D213/74 ,  C07D207/335 ,  C07D333/32 ,  C07D307/58 ,  C07D307/52 ,  C07D213/65

摘要： Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.