公开(公告)号：US20220112214A1

公开(公告)日：2022-04-14

申请号：US17274990

申请日：2019-09-06

Applicant: ARRAY BIOPHARMA INC.

Inventor： James F. BLAKE ,  Donghua DAI ,  Julia HAAS ,  Yutong JIANG ,  Dean KAHN ,  Gabrielle R. KOLAKOWSKI ,  Elizabeth A. MCFADDIN ,  Megan L. MCKENNEY ,  Andrew T. METCALF ,  David A. MORENO ,  Brett PRIGARO ,  Ginelle A. RAMANN ,  Li REN ,  Shane M. WALLS ,  Hailong ZHANG

IPC: C07D498/22 ,  C07D513/22 ,  C07D498/14 ,  A61K45/06 ,  A61K31/554 ,  A61K31/55 ,  A61K31/519 ,  C07D487/14 ,  A61P35/00

Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.