公开(公告)号：US20170029353A1

公开(公告)日：2017-02-02

申请号：US15278649

申请日：2016-09-28

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： ChiCheng Ma ,  Todd Werpy

IPC: C07C51/493 ,  C12P7/46

CPC classification number: C07C51/493 ,  C07C29/149 ,  C07C51/412 ,  C07C51/42 ,  C07D207/267 ,  C07D307/33 ,  C12P7/46 ,  C07C55/02 ,  C07C57/15 ,  C07C59/245 ,  C07C55/10

Abstract: Disclosed herein are methods for forming ammonium salts of C4 diacids in a fermentation process with simultaneous removal of divalent metal carbonate salts. The pH of fermentation broths obtained during the production of fumaric, maleic, malic, and/or succinic acid by a microorganism is controlled by using alkaline oxygen containing calcium or magnesium compounds in the hydroxide, oxide, carbonate or bicarbonate forms—forming divalent metal salts of the diacids that are partially or wholly insoluble in the broth. The calcium or magnesium salts of the diacids are substituted with ammonium by introduction of ammonium salts at elevated temperature and pressure dissolving precipitated divalent metal cation salts of the diacids and forming soluble ammonium salts thereof. Carbonate in the form of CO2 or bicarbonate is simultaneously added to the fermentation media at the elevated temperature and pressure. The temperature and pressure are then reduced forming insoluble divalent metal carbonate salts that are separated from the solubilized ammonium diacid salts. The recovered metal carbonate salts can be recycled as pH control materials in subsequent fermentation reactions. Also disclosed is use of the solubilized ammonium diacid salts directly as a reagent for hydrogenation to form the derivatives N-methyl-2-pyrrolidone (NMP) gamma-butyrolactone (GBL) and 1,4-butane-diol (BDO) in single pot reactions.

Abstract translation: 本文公开了在发酵过程中形成C4二酸铵盐的方法，同时除去二价金属碳酸盐。 在微生物生产富马酸，马来酸，苹果酸和/或琥珀酸期间获得的发酵肉汤的pH值通过在氢氧化物，氧化物，碳酸盐或碳酸氢盐形式的二价金属盐中使用含有钙或镁的化合物来控制 的部分或完全不溶于肉汤的二酸。 二元酸的钙盐或镁盐通过在升高的温度下引入铵盐和溶解二酸的沉淀二价金属阳离子盐并形成其可溶性铵盐而被铵取代。 CO 2或碳酸氢盐形式的碳酸盐在升高的温度和压力下同时加入到发酵培养基中。 然后降低温度和压力，形成不溶性二价金属碳酸盐，其与可溶性二铵酸盐分离。 回收的金属碳酸盐可以在随后的发酵反应中作为pH控制材料再循环。 还公开了将溶解的二铵二酸盐直接用作氢化的试剂以在单锅中形成N-甲基-2-吡咯烷酮（NMP）γ-丁内酯（GBL）和1,4-丁二醇（BDO） 反应。

公开(公告)号：US20150251980A1

公开(公告)日：2015-09-10

申请号：US14709591

申请日：2015-05-12

Applicant: Archer Daniels Midland Company

Inventor： Carlos Gustavo Dassori ,  Chi-Cheng Ma ,  Todd Werpy

IPC: C07C29/141

CPC classification number: C07C29/141 ,  B01J8/0242 ,  B01J8/025 ,  B01J8/0278 ,  B01J8/0457 ,  B01J8/0492 ,  B01J25/04 ,  B01J38/48 ,  B01J2208/00212

Abstract: A process is described for improving the performance of certain multiphase reaction systems including a solid catalyst, one or more reactants in the gas phase and one or more reactants in the liquid phase, wherein a targeted maximum concentration of a reactant in the liquid phase is identified for providing improved value in terms of byproduct formation, catalyst deactivation and yields of desired products, and this targeted concentration is closely approached and preferably achieved, but not substantially exceeded, downstream in a continuous process or later in time from the initiation of a batch in a semibatch mode of operation of such processes.

Abstract translation: 描述了一种用于改善某些多相反应体系（包括固体催化剂，气相中的一种或多种反应物和液相中的一种或多种反应物）的性能的方法，其中确定液相中反应物的目标最大浓度 为了在副产物形成，催化剂失活和所需产物的产率方面提供改进的价值，并且该目标浓度在连续方法中的下游或在批次的开始后的较短时间内接近并优选地实现，但是基本上不超过 这种过程的半匹配操作模式。

公开(公告)号：US10196333B2

公开(公告)日：2019-02-05

申请号：US14709591

申请日：2015-05-12

Applicant: Archer Daniels Midland Company

Inventor： Carlos Gustavo Dassori ,  Chi-Cheng Ma ,  Todd Werpy

IPC: C07C29/141 ,  B01J8/04 ,  B01J8/02 ,  B01J38/48 ,  B01J25/04

Abstract: A process is described for improving the performance of certain multiphase reaction systems including a solid catalyst, one or more reactants in the gas phase and one or more reactants in the liquid phase, wherein a targeted maximum concentration of a reactant in the liquid phase is identified for providing improved value in terms of byproduct formation, catalyst deactivation and yields of desired products, and this targeted concentration is closely approached and preferably achieved, but not substantially exceeded, downstream in a continuous process or later in time from the initiation of a batch in a semibatch mode of operation of such processes.

公开(公告)号：US09938215B2

公开(公告)日：2018-04-10

申请号：US15304666

申请日：2015-04-09

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： Chi-Cheng Ma ,  Todd Werpy

IPC: C07C29/60 ,  C07C29/151

CPC classification number: C07C29/60 ,  C07C29/1512 ,  C07C31/205

Abstract: An improved process for making bioderived propylene glycol from a feed composition including at least one of lactic acid, glycerol, a five carbon sugar, a five carbon sugar alcohol, a six carbon sugar and a six carbon sugar alcohol, wherein production of four carbon and higher diols is reduced by adding base after the initiation of the reaction. In preferred embodiments, the process pH and other process conditions are initially established at targeted values for obtaining the highest conversion for a given catalyst consistent with the production of substantially no pentanediol byproducts in the product mixture, and base is added thereafter to control the process pH proximate to the initially targeted value.

公开(公告)号：US20170036975A1

公开(公告)日：2017-02-09

申请号：US15304666

申请日：2015-04-09

Applicant: ARCHER DANIELS MIDLAND COMPANY

Inventor： Chi-Cheng Ma ,  Todd Werpy

IPC: C07C29/60

CPC classification number: C07C29/60 ,  C07C29/1512 ,  C07C31/205

Abstract: An improved process for making bioderived propylene glycol from a feed composition including at least one of lactic acid, glycerol, a five carbon sugar, a five carbon sugar alcohol, a six carbon sugar and a six carbon sugar alcohol, wherein production of four carbon and higher diols is reduced by adding base after the initiation of the reaction. In preferred embodiments, the process pH and other process conditions are initially established at targeted values for obtaining the highest conversion for a given catalyst consistent with the production of substantially no pentanediol byproducts in the product mixture, and base is added thereafter to control the process pH proximate to the initially targeted value.

Abstract translation: 一种从包含乳酸，甘油，五碳糖，五碳糖醇，六碳糖和六碳糖醇中的至少一种的饲料组合物制备生物活性丙二醇的改进方法，其中生产四碳和 在反应开始后加入碱来降低高级二醇。 在优选的实施方案中，工艺pH和其它工艺条件最初建立在目标值下，以获得与产物混合物中基本上不含戊二醇副产物的生产一致的给定催化剂的最高转化率，然后加入碱以控制工艺pH 接近最初的目标值。