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公开(公告)号：US20220169734A1
公开(公告)日：2022-06-02
申请号：US17512257
申请日：2021-10-27
申请人： AnaptysBio, Inc. , Tesaro, Inc.
发明人： David J. King , Marilyn Kehry , Srimoyee Ghosh , Baochuan Huang
摘要： The disclosure provides antibody agents that bind to a T Cell Immunoglobulin and Mucin Protein-3 (TIM-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-TIM-3 antibody agent to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.
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公开(公告)号：US20220135670A1
公开(公告)日：2022-05-05
申请号：US16608111
申请日：2018-04-27
申请人： TESARO, INC. , ANAPTYSBIO, INC.
发明人： Helen Toni Jun , Marilyn Kehry , Peter Bowers , David J. King , Dmitri Bobilev , Srimoyee Ghosh , Baochuan Huang , David Jenkins
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , A61P35/00
摘要： The disclosure provides antibody agents that bind to a Lymphocyte Activation Gene-3 (LAG-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using anti-LAG-3 antibody agents to treat a disorder or disease that is responsive to LAG-3 inhibition, such as, for example, cancer or an infectious disease.
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公开(公告)号：US20220089739A1
公开(公告)日：2022-03-24
申请号：US17486709
申请日：2021-09-27
申请人： Tesaro, Inc. , ANAPTYSBIO, INC.
发明人： David J. King , Marilyn Kehry , Baochuan Huang
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , C12N15/63
摘要： The disclosure provides antibody agents that bind to a programmed death-1 (PD-1) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-PD-1 antibody agent to treat a disorder or disease that is responsive to PD-1 inhibition, such as cancer or an infectious disease.
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4.发明公开公开(公告)号：US20240158495A1
公开(公告)日：2024-05-16
申请号：US18153749
申请日：2023-01-12
申请人： Tesaro, Inc. , Anaptysbio, Inc.
发明人： Helen Toni Jun , Marilyn Kehry , Peter Bowers , David J. King , Dmitri Bobilev , Srimoyee Ghosh , Baochuan Huang , David Jenkins
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： C07K16/2803 , A61K39/3955 , A61K45/06 , A61P35/00 , A61K2039/505
摘要： The disclosure provides antibody agents that bind to a Lymphocyte Activation Gene-3 (LAG-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using anti-LAG-3 antibody agents to treat a disorder or disease that is responsive to LAG-3 inhibition, such as, for example, cancer or an infectious disease.
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公开(公告)号：US20230416368A1
公开(公告)日：2023-12-28
申请号：US18354395
申请日：2023-07-18
申请人： AnaptysBio, Inc. , Tesaro, Inc.
发明人： David J. King , Marilyn Kehry , Srimoyee Ghosh , Baochuan Huang
CPC分类号： C07K16/2818 , A61P37/06 , A61P35/02 , C07K16/2827 , C07K16/2803 , A61K45/06
摘要： Provided herein are anti-T Cell Immunoglobulin and Mucin Protein-3 (TIM-3) antibodies having particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences and methods of using the anti-TIM-3 antibodies to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.
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公开(公告)号：US11753472B2
公开(公告)日：2023-09-12
申请号：US17512257
申请日：2021-10-27
申请人： AnaptysBio, Inc. , Tesaro, Inc.
发明人： David J. King , Marilyn Kehry , Srimoyee Ghosh , Baochuan Huang
CPC分类号： C07K16/2818 , A61P35/02 , A61P37/06 , C07K16/2803 , C07K16/2827 , A61K45/06 , C07K2317/41 , C07K2317/524 , C07K2317/53 , C07K2317/70 , C07K2317/76 , C07K2317/92 , Y02A50/30
摘要： Provided herein are anti-T Cell Immunoglobulin and Mucin Protein-3 (TIM 3) antibodies having particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences and methods of using the anti-TIM-3 antibodies to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.
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公开(公告)号：US11155624B2
公开(公告)日：2021-10-26
申请号：US16346485
申请日：2017-11-01
申请人： ANAPTYSBIO, INC. , TESARO, INC.
发明人： David J. King , Marilyn Kehry , Baochuan Huang
IPC分类号： C07K16/28 , A61K39/395 , C12N15/63 , A61K45/06 , A61K39/00
摘要： The disclosure provides antibody agents that bind to a programmed death-1 (PD-1) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-PD-1 antibody agent to treat a disorder or disease that is responsive to PD-1 inhibition, such as cancer or an infectious disease.
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公开(公告)号：US20190284280A1
公开(公告)日：2019-09-19
申请号：US16346463
申请日：2017-11-01
申请人： ANAPTYSBIO, INC. , TESARO, INC.
发明人： David J. King , Marilyn Kehry , Srimoyee Ghosh , Baochuan Huang
摘要： The disclosure provides antibody agents that bind to a T Cell Immunoglobulin and Mucin Protein-3 (TIM-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-TIM-3 antibody agent to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.
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公开(公告)号：US20190256600A1
公开(公告)日：2019-08-22
申请号：US16346485
申请日：2017-11-01
申请人： ANAPTYSBIO, INC. , TESARO, INC.
发明人： David J. King , Marilyn Kehry , Baochuan Huang
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
摘要： The disclosure provides antibody agents that bind to a programmed death-1 (PD-1) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-PD-1 antibody agent to treat a disorder or disease that is responsive to PD-1 inhibition, such as cancer or an infectious disease.
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公开(公告)号：US11999783B2
公开(公告)日：2024-06-04
申请号：US17071046
申请日：2020-10-15
申请人： AnaptysBio, Inc.
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
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