公开(公告)号：US20230137351A1

公开(公告)日：2023-05-04

申请号：US16349965

申请日：2017-11-14

Applicant: AMGEN INC.

Inventor： Wei YAN ,  Zhi LIU ,  Christopher MURAWSKY ,  Chadwick Terence KING ,  Yang LI ,  Zhonghua HU ,  Desiree LIM

IPC: C07K16/46

Abstract: The present invention relates to bispecific or biparatopic antigen binding proteins, polynucleotides encoding the same, and methods of making bispecific or biparatopic antigen binding proteins. Also described herein is a method to assemble IgG-like biparatopic or bispecific antibodies from VH only antigen binding proteins.

公开(公告)号：US20200010545A1

公开(公告)日：2020-01-09

申请号：US16413810

申请日：2019-05-16

Applicant: AMGEN INC.

Inventor： Zhi LIU ,  Gunasekaran KANNAN ,  Wei YAN

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.

公开(公告)号：US20220402985A1

公开(公告)日：2022-12-22

申请号：US17836425

申请日：2022-06-09

Applicant: Amgen Inc.

Inventor： Darren L. BATES ,  Zhi LIU ,  TaeWeon LEE ,  Mark L. MICHAELS ,  Zhulun WANG

IPC: C07K14/485 ,  A61P9/10

Abstract: The present invention relates to engineered neuregulin-1 variants that selectively activate ErbB4 receptors but do not activate ErbB3 receptors. The invention also provides methods for using such variants to treat heart failure.

公开(公告)号：US20160046705A1

公开(公告)日：2016-02-18

申请号：US14443107

申请日：2013-11-21

Applicant: AMGEN INC.

Inventor： Gunasekaran KANNAN ,  Monica FLORIO ,  Zhi LIU ,  Wei YAN

IPC: C07K16/22 ,  C07K16/18

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The present application is directed to heterodimeric antibodies and methods of use.

Abstract translation: 本申请涉及异二聚体抗体和使用方法。