公开(公告)号：US09850297B2

公开(公告)日：2017-12-26

申请号：US14776012

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Jiangwen Majeti ,  YuMei Xiong ,  Wen-Chen Yeh ,  Alykhan S. Motani ,  Yang Li

IPC: C07K16/18 ,  C12N5/10 ,  C12N15/10 ,  C12N15/11 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the SFRP5 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US12054527B2

公开(公告)日：2024-08-06

申请号：US16620029

申请日：2019-04-08

Applicant: Amgen Inc.

Inventor： YuMei Xiong ,  Kenneth William Walker ,  Murielle Marie Veniant Ellison

IPC: C07K14/495 ,  A61K38/00

CPC classification number: C07K14/495 ,  A61K38/00 ,  C07K2319/30

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US11161889B2

公开(公告)日：2021-11-02

申请号：US17148761

申请日：2021-01-14

Applicant: Amgen Inc.

Inventor： YuMei Xiong ,  Kenneth William Walker ,  Murielle Marie Veniant Ellison

IPC: C07K14/495

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.