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公开(公告)号：US20220348542A1
公开(公告)日：2022-11-03
申请号：US17728575
申请日：2022-04-25
Applicant: AMGEN INC.
Inventor： Matthew G. Beaver , Carolyn Cohen , Neil Fred Langille , Simone Spada
IPC: C07D209/48
Abstract: Provided herein are processes for synthesizing apremilast comprising reacting 3-acetamidophthalic anhydride and (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine or a salt thereof to form apremilast. Also provided are processes for isolating apremilast from the reaction mixture, as described herein.
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