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公开(公告)号：US20210301020A1
公开(公告)日：2021-09-30
申请号：US17262339
申请日：2019-07-17
Applicant: AMGEN INC.
Inventor： Xin YU , Wenjun OUYANG , Chi-Ming Kevin LI , Jackson Graeme EGEN , Oh Kyu YOON , Ian Halsey DRIVER , Shunsuke TAKENAKA , Christy Ann THOMSON , Hongyu WANG
Abstract: This invention relates to combination therapies comprising a Programmed Death 1 receptor (PD-1) pathway inhibitor, and a Leukocyte Immunoglobulin Like Receptor B (LILRB) signaling inhibitor, and the use of the combination therapies for the treatment of cancer. The invention also relates to the treatment of cancer patients who are refractory to monotherapy with a PD-1 pathway inhibitor.
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2.发明公开公开(公告)号：US20240150481A1
公开(公告)日：2024-05-09
申请号：US18417708
申请日：2024-01-19
Applicant: Amgen Inc.
Inventor： Xin YU , Jackson EGEN , Fernando GARCES , Shunsuke TAKENAKA , AeRyon KIM , Deepali SAWANT
CPC classification number: C07K16/2878 , A61P35/04 , C07K16/30 , A61K2039/505
Abstract: The present invention relates to a human agonistic CD40 multispecific antibody construct for treatment of solid tumors by engineering a molecule that specifically targets the CD40 pathway on tumor-associated APCs, without systemic CD40 activation.
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公开(公告)号：US20230381276A1
公开(公告)日：2023-11-30
申请号：US18072959
申请日：2022-12-01
Applicant: AMGEN INC.
Inventor： Khaled M.K.Z. ALI , Neeraj Jagdish AGRAWAL , Gunasekaran KANNAN , Ian FOLTZ , Zhulun WANG , Darren BATES , Marissa MOCK , Shunsuke TAKENAKA
CPC classification number: A61K38/20 , C12N15/63 , A61P35/00 , C07K16/283 , C07K14/54 , A61K47/6849 , A61K47/6813 , C12N2740/10041
Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.
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公开(公告)号：US20210347905A1
公开(公告)日：2021-11-11
申请号：US17127629
申请日：2020-12-18
Applicant: Amgen Inc.
Inventor： Xin YU , Jackson EGEN , Fernando GARCES , Shunsuke TAKENAKA , AeRyon KIM , Deepali SAWANT
Abstract: The present invention relates to a human agonistic CD40 multispecific antibody construct for treatment of solid tumors by engineering a molecule that specifically targets the CD40 pathway on tumor-associated APCs, without systemic CD40 activation.
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