公开(公告)号：US20170166942A1

公开(公告)日：2017-06-15

申请号：US15115615

申请日：2014-12-11

Applicant: AMGEN INC.

Inventor： Shivani GUPTA ,  Sohye KANG

IPC: C12P21/00 ,  C07K14/705 ,  C07K16/00 ,  C12N9/10

CPC classification number: C12P21/005 ,  C07K14/705 ,  C07K16/00 ,  C07K2317/41 ,  C12N9/1051 ,  C12Y204/01101 ,  C12Y204/01143

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the overexpression of proteins involved in the N-glycosylation pathway.

公开(公告)号：US20190153496A1

公开(公告)日：2019-05-23

申请号：US16261311

申请日：2019-01-29

Applicant: AMGEN INC.

Inventor： Shivani GUPTA ,  Sohye KANG

IPC: C12P21/00 ,  C07K16/00 ,  C12N9/10 ,  C07K14/705 ,  C12N15/85

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the overexpression of proteins involved in the N-glycosylation pathway.

公开(公告)号：US20200277642A1

公开(公告)日：2020-09-03

申请号：US16875832

申请日：2020-05-15

Applicant: AMGEN INC.

Inventor： Shivani GUPTA ,  Sohye KANG

IPC: C12P21/00 ,  C12N9/10 ,  C12N15/85 ,  C07K14/705 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the overexpression of proteins involved in the N-glycosylation pathway.

公开(公告)号：US20190010532A1

公开(公告)日：2019-01-10

申请号：US16130879

申请日：2018-09-13

Applicant: AMGEN INC.

Inventor： Shivani GUPTA ,  Sohye KANG

IPC: C12P21/00 ,  C07K16/00 ,  C07K14/705 ,  C12N9/10

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the overexpression of proteins involved in the N-glycosylation pathway.