公开(公告)号：US20140045855A1

公开(公告)日：2014-02-13

申请号：US13958478

申请日：2013-08-02

Applicant: AMGEN INC.

Inventor： Kaustav BISWAS ,  Jian J. CHEN ,  Vijay Keshav GORE ,  Scott HARRIED ,  Daniel B. HORNE ,  Matthew R. KALLER ,  Vu Van MA ,  Kelvin SHAM ,  Wenge ZHONG

IPC: C07D491/052 ,  C07D401/12

CPC classification number: C07D491/052 ,  C07D215/40 ,  C07D311/68 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04

Abstract: Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Abstract translation: 色甘酸化合物和式I的衍生物是TRPM8的有用抑制剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构：其中本文提供变量的定义。