公开(公告)号：US09920114B2

公开(公告)日：2018-03-20

申请号：US15460961

申请日：2017-03-16

Applicant: AMGEN INC.

Inventor： Bruce D. Mason ,  Jifeng Zhang ,  Richard L. Remmele, Jr.

IPC: C07K16/18 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/39591 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/56 ,  C07K2317/76

Abstract: Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.

公开(公告)号：US10166189B2

公开(公告)日：2019-01-01

申请号：US15011229

申请日：2016-01-29

Applicant: AMGEN INC.

Inventor： William J. Callahan ,  Richard L. Remmele, Jr. ,  Gayathri Ratnaswamy ,  Ramil F. Latypov ,  Dingjiang Liu

IPC: A61K39/395 ,  A61K9/19 ,  A61K38/10 ,  A61K38/16 ,  A61K47/22 ,  A61K47/26

Abstract: The present invention provides long-term stable formulations of a lyophilized therapeutic peptibody and methods for making a lyophilized composition comprising a therapeutic peptibody.