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公开(公告)号：US20210346513A1
公开(公告)日：2021-11-11
申请号：US16636325
申请日：2018-08-03
Applicant: AMGEN INC.
Inventor： Michal ACHMATOWICZ , Dante ROMANINI , James R. FALSEY , Bradley J. HERBERICH , Oliver R. THIEL
IPC: A61K47/68 , C07K16/28 , C07K14/605
Abstract: The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that offer high yield and consistent product quality.
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