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公开(公告)号：US20160257748A1
公开(公告)日：2016-09-08
申请号：US14916207
申请日：2014-09-25
Applicant: AMGEN INC.
Inventor： Mark L. Michaels , Luis G Borges , Wei Yan
CPC classification number: C07K16/2803 , C07K16/28 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: Described herein is a dimeric, bispecific antibody format. Each polypeptide chain of the dimer comprises an immunoglobulin variable region, an immunoglobulin constant region, an Fc polypeptide chain, another immunoglobulin variable region, and another immunoglobulin constant region. Also described are methods of making and using such antibodies.
Abstract translation: 本文描述的是二聚双特异性抗体形式。 二聚体的每个多肽链包含免疫球蛋白可变区，免疫球蛋白恒定区，Fc多肽链，另一个免疫球蛋白可变区和另一个免疫球蛋白恒定区。 还描述了制备和使用这些抗体的方法。
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公开(公告)号：US20160145340A1
公开(公告)日：2016-05-26
申请号：US14774309
申请日：2014-03-14
Applicant: AMGEN INC.
Inventor： Luis G. Borges , Patrick Baeuerle , Wei Yan , Mark L. Michaels
Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.
Abstract translation: 本文描述的是含有Fc多肽链和免疫球蛋白可变区的双特异性分子。 还提供了包含这种分子的药物制剂，编码这种分子的核酸，含有这种核酸的宿主细胞，制备这种分子的方法，以及使用这种分子的方法。
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公开(公告)号：US11634502B2
公开(公告)日：2023-04-25
申请号：US14774320
申请日：2014-03-13
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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公开(公告)号：US20230055407A1
公开(公告)日：2023-02-23
申请号：US17702131
申请日：2022-03-23
Applicant: AMGEN INC.
Inventor： Mark L. Michaels , Luis G. Borges , Wei Yan
Abstract: Described herein is a dimeric, bispecific antibody format. Each polypeptide chain of the dimer comprises an immunoglobulin variable region, an immunoglobulin constant region, an Fc polypeptide chain, another immunoglobulin variable region, and another immunoglobulin constant region. Also described are methods of making and using such antibodies.
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公开(公告)号：US20180230220A1
公开(公告)日：2018-08-16
申请号：US15885998
申请日：2018-02-01
Applicant: AMGEN INC.
Inventor： Luis G. Borges , Patrick A. Baeuerle , Wei Yan , Mark L. Michaels
Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.
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Patent Agency Ranking
公开(公告)号：US11753475B2
公开(公告)日：2023-09-12
申请号：US15885998
申请日：2018-02-01
Applicant: AMGEN INC.
Inventor： Luis G. Borges , Patrick A. Baeuerle , Wei Yan , Mark L. Michaels
CPC classification number: C07K16/2863 , C07K16/00 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/32 , C07K16/40 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2319/00
Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.
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公开(公告)号：US20230077648A1
公开(公告)日：2023-03-16
申请号：US17722724
申请日：2022-04-18
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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公开(公告)号：US20200071425A1
公开(公告)日：2020-03-05
申请号：US16383115
申请日：2019-04-12
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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公开(公告)号：US20200040075A1
公开(公告)日：2020-02-06
申请号：US16352213
申请日：2019-03-13
Applicant: AMGEN INC.
Inventor： Mark L. Michaels , Luis G. Borges , Wei Yan
Abstract: Described herein is a dimeric, bispecific antibody format. Each polypeptide chain of the dimer comprises an immunoglobulin variable region, an immunoglobulin constant region, an Fc polypeptide chain, another immunoglobulin variable region, and another immunoglobulin constant region. Also described are methods of making and using such antibodies.
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公开(公告)号：US20160115241A1
公开(公告)日：2016-04-28
申请号：US14774320
申请日：2014-03-13
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
CPC classification number: C07K16/30 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/60 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/94
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
Abstract translation: 本文提供了可以通过免疫效应细胞介导靶细胞的细胞溶解的异二聚体双特异性抗体，编码这种抗体的核酸，制备此类抗体的方法以及使用这种抗体的方法。 这些抗体包含两个不同的多肽链，每条链包含两个免疫球蛋白可变区和任选的半衰期延长部分。
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