公开(公告)号：US20250163023A1

公开(公告)日：2025-05-22

申请号：US19029945

申请日：2025-01-17

Applicant: Amgen Inc.

Inventor： Sebastien CAILLE ,  Kyle QUASDORF ,  Philipp C. ROOSEN ,  Xianqing SHI ,  Andrew COSBIE ,  Fang WANG ,  Zufan WU ,  Archana NEERGUNDA ,  Bin Peter QUAN ,  Lianxiu GUAN

IPC: C07D401/12 ,  C07D241/04

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.

公开(公告)号：US20250129072A1

公开(公告)日：2025-04-24

申请号：US18987521

申请日：2024-12-19

Applicant: AMGEN INC.

Inventor： Michal ACHMATOWICZ ,  John T. COLYER ,  Michael T. CORBETT ,  Daniel J. GRIFFIN ,  Andrew T. PARSONS ,  Joanna ROBINSON ,  Kyle QUASDORF

IPC: C07D471/04

Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

公开(公告)号：US20220298099A1

公开(公告)日：2022-09-22

申请号：US17690729

申请日：2022-03-09

Applicant: Amgen Inc.

Inventor： Sebastien CAILLE ,  James MURRAY ,  Kyle QUASDORF ,  Hannah NGUYEN ,  Maria Victoria SILVA ELIPE ,  Ari Elizabeth ERICSON

IPC: C07C201/08

Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

公开(公告)号：US20240199550A1

公开(公告)日：2024-06-20

申请号：US18416741

申请日：2024-01-18

Applicant: Amgen Inc. ,  Cytokinetics, Inc.

Inventor： Henry MORRISON ,  Sheng CUI ,  Kyle QUASDORF ,  Evelyn YANEZ ,  Bin Peter QUAN ,  Ron C. KELLY ,  Sebastien CAILLE ,  Lingyun XIAO ,  David PEARSON ,  Jaclyn RAEBURN ,  Alisa GOLIGHTLY ,  Bradley MORGAN ,  Matthew PETERSON ,  Alex EBERLIN ,  Alexander OBLEZOV

IPC: C07D213/75

CPC classification number: C07D213/75 ,  C07B2200/13

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

公开(公告)号：US20240025896A1

公开(公告)日：2024-01-25

申请号：US18253285

申请日：2021-11-19

Applicant: AMGEN INC.

Inventor： Michal ACHMATOWICZ ,  John T. COYLER ,  Michael T. CORBETT ,  Daniel J. GRIFFIN ,  Andrew T. PARSONS ,  Joanna ROBINSON ,  Kyle QUASDORF

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes [Insert Structure] (Compound A).

公开(公告)号：US20230373955A1

公开(公告)日：2023-11-23

申请号：US18359467

申请日：2023-07-26

Applicant: Amgen Inc.

Inventor： Sebastien CAILLE ,  Kyle QUASDORF ,  Philipp C. ROOSEN ,  Xianqing SHI ,  Andrew COSBIE ,  Fang WANG ,  Zufan WU ,  Archana NEERGUNDA ,  Bin Peter QUAN ,  Lianxiu GUAN

IPC: C07D401/12 ,  C07D241/04

CPC classification number: C07D401/12 ,  C07D241/04

Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)