公开(公告)号：US10689367B2

公开(公告)日：2020-06-23

申请号：US16347970

申请日：2017-11-03

Applicant: AMGEN INC.

Inventor： Yinhong Chen ,  Alan C. Cheng ,  Mikkel V. Debenedetto ,  Paul John Dransfield ,  James S. Harvey ,  Jonathan Houze ,  Aarif Yusuf Khakoo ,  Su-Jen Lai ,  Zhihua Ma ,  Vatee Pattaropong ,  Gayathri Swaminath ,  Charles Kreiman ,  David C. Moebius ,  Ankit Sharma

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61P9/04 ,  C07D417/14 ,  A61K45/06 ,  C07D401/12

Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.