公开(公告)号：US20250122224A1

公开(公告)日：2025-04-17

申请号：US18730353

申请日：2023-02-03

Applicant: AMGEN INC.

Inventor： Ron C. Kelly ,  Mary Chaves ,  Jing Teng ,  Stephan Parent ,  Van Luu ,  Robert P. Farrell ,  James E. Huckle ,  Michal Achmatowicz ,  Tian Wu ,  Darren Leonard Reid ,  Lingyun Xiao

IPC: C07D519/00 ,  A61K31/553

Abstract: Disclosed herein are salt and solvate forms of (4S,7aR,9aR,10R,11E,14S,15R)-6′-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3′,4′,7a,8,9,9a,10,13,14,15-decahydro-2′H,3H,5H-spiro[1,19-etheno-16,16-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadlazacyclohexadecine-4,1 naphthalene]-16,16,18 (7H,17H)-trione (AMG 397): (AMG 397), such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.

公开(公告)号：US20250115622A1

公开(公告)日：2025-04-10

申请号：US18730357

申请日：2023-02-03

Applicant: AMGEN INC.

Inventor： Ron C. Kelly ,  Mary Chaves ,  Jing Teng ,  Stephan Parent ,  Markian Stec ,  Van Luu ,  Robert P. Farrell ,  James E. Huckle ,  Michal Achmatowicz ,  Tian Wu ,  Darren Leonard Reid ,  Lingyun Xiao

IPC: C07D519/00 ,  A61K31/553

Abstract: Disclosed herein are crystalline forms of (4S,7aR,9aR,10R,11E,14S,15R)-6′-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3′,4′,7a,8,9,9a,10,13,14,15-decahydro-2′H,3H,5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1′-naphthalene]-16,16,18(7H,17H)-trione (AMG 397): (AMG 397), hydrates, and solvates thereof. Also disclosed are methods of making the crystalline forms, and methods of treating diseases and disorders with the crystalline forms.

公开(公告)号：US11236091B2

公开(公告)日：2022-02-01

申请号：US16878824

申请日：2020-05-20

Applicant: AMGEN INC.

Inventor： Mary Chaves ,  Patricia Lopez ,  Prashant Agarwal ,  Albert Amegadzie ,  Stephanie Azali ,  Roman Shimanovich ,  Ron C. Kelly ,  Darren Leonard Reid

IPC: C07D471/04

Abstract: The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

公开(公告)号：US12252486B2

公开(公告)日：2025-03-18

申请号：US17612717

申请日：2020-05-20

Applicant: Amgen Inc.

Inventor： Mary Chaves ,  Ron C. Kelly ,  Prashant Agarwal ,  Stephan D. Parent ,  Darren Leonard Reid ,  Roman Shimanovich

IPC: C07D471/04 ,  A61P35/00

Abstract: The present invention provides a crystalline form and stable salts of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several hydrochloride salt forms, phosphate salt form, mesylate salt form, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

公开(公告)号：US20250054585A1

公开(公告)日：2025-02-13

申请号：US18798152

申请日：2024-08-08

Applicant: AMGEN INC,

Inventor： Mohammad Bonakdar ,  Vilmali Lopez-Mejias ,  Marzieh Ataei ,  Padmini Kavuru Ananthoji ,  Darren Leonard Reid ,  Michael A. Lovette ,  Michael Ingram

IPC: G16C20/80 ,  G06F3/04817 ,  G16B15/30 ,  G16B50/00

Abstract: A computer-implemented method can comprise, at a display device, displaying, via the display device, a first user interface corresponding to one or more molecules; receiving, via the display device, one or more first user inputs associated with the one or more molecules, wherein the one or more first user inputs comprise selecting a subset of the one or more molecules; and in response to selecting the subset of the one or more molecules, displaying, via the display device, a second user interface corresponding to a form map associated with the subset of the one or more molecules.

公开(公告)号：US11827635B2

公开(公告)日：2023-11-28

申请号：US17553598

申请日：2021-12-16

Applicant: AMGEN INC.

Inventor： Mary Chaves ,  Patricia Lopez ,  Prashant Agarwal ,  Albert Amegadzie ,  Stephanie Azali ,  Roman Shimanovich ,  Ron C. Kelly ,  Darren Leonard Reid

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07B2200/13

Abstract: The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.