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公开(公告)号：US20180280474A1
公开(公告)日：2018-10-04
申请号：US15765144
申请日：2016-09-30
Applicant: AMGEN INC.
Inventor： Jing Xu , Shanaka Stanislaus , Mei-Hsiu M. Chen , Clarence H. Hale , Murielle Veniant-Ellison
Abstract: The invention relates method of treating a patient in need thereof with a long acting agonist to the FGF21 signaling pathway. In a particular embodiment, the invention relates to the use of molecules that stimulate the FGF21 signaling pathway, such as long acting FGF21 polypeptides or agonist antibodies, to treat disorders or diseases associated with excess bile acid. The invention further relates to pharmaceutical formulations and dosing of long acting agonists of the FGF21 signaling pathway suitable for treating bile acid related disorders.
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