公开(公告)号：US20160333385A1

公开(公告)日：2016-11-17

申请号：US15111470

申请日：2014-12-09

Applicant: AMGEN INC.

Inventor： Sohye KANG ,  Chung HUANG, Jr. ,  Hedieh BARKHORDARIAN ,  Pavel BONDARENKO ,  Zhongqi ZHANG

IPC: C12P21/00 ,  C12N5/071 ,  C07K14/52 ,  C07K16/00

Abstract: The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.

Abstract translation: 本发明涉及通过调节细胞培养过程中的鸟氨酸代谢来操纵重组糖蛋白的高甘露糖糖型含量的方法。