公开(公告)号：US20230167175A1

公开(公告)日：2023-06-01

申请号：US17921793

申请日：2021-04-28

Applicant: AMGEN INC.

Inventor： Twinkle R. Christian ,  Bharadwaj Jagannathan ,  Andrew Dykstra

IPC: C07K16/28 ,  C07K16/30 ,  A61K47/18 ,  A61K47/26

CPC classification number: C07K16/2809 ,  C07K16/2803 ,  C07K16/30 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/2875 ,  C07K16/28 ,  A61K47/183 ,  A61K47/26 ,  C07K2317/622 ,  C07K2317/31

Abstract: The present disclosure describes stable aqueous formulations comprising, e.g., a bispecific antibody construct, a buffer, a saccharide and a surfactant, the formulation having a pH 4.8-5.5.