公开(公告)号：US20250074855A1

公开(公告)日：2025-03-06

申请号：US18291294

申请日：2022-08-17

Applicant: AMGEN INC.

Inventor： Adrian ORTIZ ,  Athimoolam ARUNACHALAMPILLAI

IPC: C07C51/09 ,  C07C17/18 ,  C07C51/42

Abstract: The present invention relates to stereoselective process for the preparation of a compound having formula (2) and (1) wherein X is defined in the specification.

公开(公告)号：US20240360079A1

公开(公告)日：2024-10-31

申请号：US18291285

申请日：2022-08-17

Applicant: AMGEN INC.

Inventor： Adrian ORTIZ ,  Jaika DOERFLER ,  Karina R. VAIDA

IPC: C07C319/12 ,  C07C321/26 ,  C12P13/00

CPC classification number: C07C319/12 ,  C07C321/26 ,  C12P13/001

Abstract: The present invention relates to precious metal (Pd/Pt/Rh/Ru) free, preferably Pd free, processes for preparing a compound having formula (1) wherein: R1, R2, and X are as defined in the specification, or a salt thereof. Preferably, the compound is an iodo acrylate compound.