公开(公告)号：US20160030413A1

公开(公告)日：2016-02-04

申请号：US14777111

申请日：2014-03-14

Applicant: ALUMEND, LLC

Inventor： Barbara R. HABERER ,  Therese J. DOWNEY ,  Ronald E. UTECHT

IPC: A61K31/473 ,  A61K41/00 ,  A61N5/06 ,  A61K9/00

CPC classification number: A61K31/473 ,  A61K9/0019 ,  A61K41/0042 ,  A61K45/06 ,  A61N5/062 ,  A61N2005/0602 ,  A61K2300/00 ,  A61K41/00

Abstract: Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

Abstract translation: 本文公开了用于组合物中应用于血管的化合物，其中所述化合物软化和/或破坏钙化斑块的结晶基质，以及急性恢复血管治疗部位的血管依从性，同时保持 血管成形术期间的腔内增益。 还公开了应用所公开的组合物的治疗方法。 还公开了斑块软化化合物。