公开(公告)号：US11413301B2

公开(公告)日：2022-08-16

申请号：US16470532

申请日：2017-12-18

申请人： ALTREGEN CO., LTD.

发明人： Yunhee Lee ,  Ali Hussain ,  Dae Bong Kim

IPC分类号： A61K31/704 ,  A61K35/616

摘要： The present invention relates to a composition for preventing and treating a Bruch's membrane dysfunction-associated disease, which includes a sea cucumber extract as an active ingredient, and more particularly, to a composition for preventing and treating a Bruch's membrane dysfunction-associated disease, which includes a sea cucumber extract having effects of regenerating the Bruch's membrane of an eye and improving a transport function. The composition according to the present invention improves the transport function of the Bruch's membrane and promotes the regeneration of the Bruch's membrane, thereby delaying or reversing an eye aging process, and thus has excellent effects on the prevention and treatment of a disease such as age-related macular degeneration (AMD), Sorsby's fundus dystrophy, Malattia Levintanese (ML), Stargardt disease, Best's vitelliform retinal dystrophy and Doyne's honeycomb retinal dystrophy (DHRD), which occurs due to the age-related dysfunction of the Bruch's membrane.

公开(公告)号：US10940168B2

公开(公告)日：2021-03-09

申请号：US16484570

申请日：2018-02-08

申请人： ALTREGEN CO., LTD.

发明人： Yunhee Lee ,  Ali Hussain ,  Dae Bong Kim

IPC分类号： A61K35/616 ,  A61P27/02 ,  A61K9/00 ,  A61K36/258

摘要： A composition includes a sea cucumber and ginseng/red ginseng composite extract which has the effect of regenerating the Bruch's membrane of the eye and improving the transport function of the Bruch's membrane. The composite composition improves the transport function of the Bruch's membrane and eliminates lipids accumulated on the membrane to promote the regeneration of the Bruch's membrane, thereby showing the effect of delaying or reversing the senescence process of the eye. Further, the composition is highly preventive or therapeutic of various diseases attributed to a decrease in the function of the Bruch's membrane with age, including age-related macular degeneration (AMD) and can solve the problem associated with the eye health maintenance of ordinary persons and with the transport reduction, resulting from senescence, of vitamins, metals, and anti-oxidative materials.