公开(公告)号：US20190336551A1

公开(公告)日：2019-11-07

申请号：US16307683

申请日：2017-06-08

申请人： ALMA MATER STUDIORUM UNIVERSITA DI BOLOGNA

发明人： MARIA GABRIELLA CAMPADELLI ,  BILJANA PETROVIC

IPC分类号： A61K35/763 ,  C07K14/035 ,  C12N15/62 ,  C12N15/86 ,  C12N5/10 ,  C12N7/00 ,  C07K14/47

摘要： The present invention is directed to a recombinant herpesvirus comprising a heterologous polypeptide ligand capable of binding to a target molecule and fused to or inserted into glycoprotein B at specific sites. The herpesvirus may comprise more than one ligand, and the additional ligand(s) may be comprised by a modified glycoprotein D and/or modified glycoprotein H. This allows the herpesvirus to target a cell for therapeutic purposes, and a cell for virus production. The present invention further comprises a pharmaceutical composition comprising the herpesvirus, the herpesvirus for use in the treatment of a tumor, infection, degenerative disorder or senescence-associated disease, a nucleic acid and a vector coding for the gB, a polypeptide comprising the gB, and a cell comprising the herpesvirus, nucleic acid, vector or polypeptide. Moreover, a method for infecting a cell with the herpesvirus or for producing the herpesvirus is disclosed.