公开(公告)号：US20210244677A1

公开(公告)日：2021-08-12

申请号：US17251601

申请日：2018-06-14

Applicant: ALMA MATER STUDIORUM - UNIVERSITÀ DI BOLOGNA

Inventor： Laura CALZA ,  Luciana GIARDINO ,  Maria Letizia FOCARETE ,  Chiara GUALANDI ,  Maria-Laura BOLOGNESI ,  Nadia PASSERINI ,  Giampiero PAGLIUCA ,  Teresa GAZZOTTI ,  Elisa ZIRONI

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/192 ,  A61K31/198 ,  A61P25/28 ,  A61K31/4418 ,  A61K31/704 ,  A61K31/196 ,  A61K31/5415 ,  A61K31/19 ,  A61K31/405 ,  A61K31/12 ,  A61K31/407 ,  A61K31/421 ,  A61K31/197 ,  A61K31/5575 ,  A61K31/40 ,  A61K31/42 ,  A61K31/603

Abstract: The present invention relates to electro spun fibers for a local release in the central nervous system of an anti-inflammatory and a promyelinating agent over a defined time-window, in order to limit secondary neurodegeneration triggered by the glutamate release and supported by on-going inflammation. The combined treatment aimed to reduce inflammation and improve remyelination in the very early stage of the pathology improving the chronic clinical outcome of the lesion. In particular the present invention relates to electrospunpolymeric fibers, wherein said fibers are loaded with 3,3,5-Triiodo-L-thyronine (T3) and Ibuprofen.