公开(公告)号：US20190125835A1

公开(公告)日：2019-05-02

申请号：US16174293

申请日：2018-10-30

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hee Young KANG ,  Tae Jun PARK ,  Jung Eun YOON ,  Mi Sun KIM

IPC: A61K38/18 ,  A61P17/00 ,  C12N15/62 ,  A61Q19/02

Abstract: A method of preventing or treating cutaneous pigmentation disease in a subject in need thereof, includes: providing a pharmaceutical composition comprising SDF1, an inducer or activator of SDF1, as an active ingredient; and administering the pharmaceutical composition to the subject, wherein the cutaneous pigmentation is prevented or treated, and the cutaneous pigmentation disease is selected from the group consisting of melasma, freckles, lentigo, nevus, pigmentation by drugs, pigmentation after inflammation and hyperpigmentation incurred from dermatitis.

公开(公告)号：US20210310072A1

公开(公告)日：2021-10-07

申请号：US17262749

申请日：2019-07-17

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hee Young KANG ,  Tae Jun PARK ,  Jung Eun YOON

IPC: C12Q1/6883 ,  G01N33/50

Abstract: A method of screening a skin whitening agent uses the stromal cell-derived factor 1 (SDF1) promoter region, the correlation between the expression amount of the skin pigment and the expression of the SDF1 promoter is observed and thus it is expected to be available in systems for pre-screening pigmentation substances and pigment reduction materials, and the drugs screened by the method is used for treatment of skin pigment-related diseases.