公开(公告)号：US20240132458A1

公开(公告)日：2024-04-25

申请号：US18275470

申请日：2022-01-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sangdun CHOI ,  Muhammad HASEEB ,  Javaid NASIR ,  Yasmeen FARZANA ,  Jee Yeon SEO ,  Jae Kyung HEO ,  Ho Chul SHIN

IPC: C07D277/82 ,  A61P25/28 ,  C07D417/12

CPC classification number: C07D277/82 ,  A61P25/28 ,  C07D417/12

Abstract: A NLRP3-inhibitory compound 7 (NIC7) and a potent derivative NIC7w are disclosed. NLRP3-inhibitory compound 7 (NIC7) and a potent derivative NIC7w are a novel small-molecule inhibitor for inhibiting NLRP3 inflammasomes are identified. These compounds inhibit main elements of the NLRP3 signaling pathway, primarily IL-1β and caspase 1, and improve cognitive behaviors of mice in Alzheimer disease mouse models. Compositions of NIC7 and NIC7w are suitable as a therapeutic agent in treating, preventing, or improving the conditions of Alzheimer's disease.