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    BIOMARKER FOR DIAGNOSING TOXICITY OF NANOPARTICLES AND METHOD FOR EVALUATING TOXICITY OF NANOPARTICLES USING THE SAME
    2.
    发明申请
    BIOMARKER FOR DIAGNOSING TOXICITY OF NANOPARTICLES AND METHOD FOR EVALUATING TOXICITY OF NANOPARTICLES USING THE SAME 有权
    用于诊断纳米颗粒毒性的生物标记物和使用该纳米颗粒评估纳米颗粒的毒性的方法

    公开(公告)号：US20140024545A1

    公开(公告)日：2014-01-23

    申请号：US13760450

    申请日：2013-02-06

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Woo Young SHIM ,  Duc Toan Nguyen ,  Gwang Lee ,  Man Jeong Paik ,  Jae Ho Kim ,  Sang Mi Hyun ,  Ki Ryung Choi ,  Sung Su Park ,  Jin Seok Kang ,  Jeom Soon Shim

    IPC: C12Q1/02 ,  C12Q1/68

    CPC classification number: C12Q1/025 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/5091 ,  G01N2800/40 ,  G01N2800/60

    Abstract: The present invention relates to a biomarker composition for diagnosing the toxicity of nanoparticles, which shows a change in expression by exposure to the nanoparticles, the biomarker composition comprising at least one gene selected from the group consisting of aldehyde dehydrogenase, glutamic-pyruvate transaminase, glutamate dehydrogenase, glutamicoxaloacetic transaminase, glutamic acid decarboxylase and glutamate-ammonia ligase, and to a method for evaluating the toxicity of nanoparticles using the same. The biomarker is a gene marker having a high correlation with the toxicity of nanoparticles, and the use of the biomarker can determine whether nanoparticles have toxicity, with high detection sensitivity. Also, the method is useful in monitoring or evaluating the toxicity of nanoparticles by analyzing factors having a high correlation with toxicity of nanoparticles. Furthermore, the method can be effectively used as a tool for studying various diseases caused by exposure to nanoparticles or evaluating the effects of nanoparticles on health.

    Abstract translation: 本发明涉及用于诊断纳米颗粒的毒性的生物标志物组合物，其通过暴露于纳米颗粒而显示出表达变化，所述生物标志物组合物包含至少一种选自醛脱氢酶，谷氨酸 - 丙酮酸转氨酶，谷氨酸 脱氢酶，谷氨酰氧乙酰转氨酶，谷氨酸脱羧酶和谷氨酸 - 氨连接酶，以及评价使用其的纳米粒子的毒性的方法。 生物标志物是与纳米颗粒的毒性高度相关的基因标记，并且使用生物标志物可以确定纳米颗粒是否具有毒性，具有高检测灵敏度。 此外，该方法通过分析与纳米颗粒的毒性高度相关的因素来监测或评估纳米颗粒的毒性是有用的。 此外，该方法可以有效地用作研究由纳米颗粒暴露或评估纳米颗粒对健康的影响而引起的各种疾病的工具。

    COATING METHOD USING PARTICLE ALIGNMENT AND PARTICLE COATED SUBSTRATE MANUFACTURED THEREBY
    5.
    发明申请
    COATING METHOD USING PARTICLE ALIGNMENT AND PARTICLE COATED SUBSTRATE MANUFACTURED THEREBY 有权
    使用颗粒对准的涂布方法和制造的颗粒涂层基材

    公开(公告)号：US20150165476A1

    公开(公告)日：2015-06-18

    申请号：US14372118

    申请日：2013-11-27

    Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Jae Ho Kim ,  Hyo Sop Kim

    IPC: B05D3/12 ,  C09D125/06 ,  C09D1/00

    CPC classification number: B05D3/12 ,  B05D7/02 ,  B81C1/00031 ,  B81C1/0038 ,  C09D1/00 ,  C09D125/06 ,  Y10T428/24612

    Abstract: Disclosed is a coating method using particle alignment, including preparing a cohesive polymer substrate having a smooth surface; and coating the smooth surface of the cohesive polymer substrate with a plurality of particles while forming recesses respectively corresponding to the particles on the smooth surface of the cohesive polymer substrate by pressing the particles to the cohesive polymer substrate, so that binding properties between the particles and the cohesive polymer substrate are enhanced.

    Abstract translation: 公开了一种使用粒子排列的涂布方法，包括制备具有光滑表面的内聚聚合物基材; 并且用多个颗粒涂覆粘合聚合物基材的光滑表面，同时通过将颗粒压到粘合性聚合物基材上，形成分别对应于粘合聚合物基材的光滑表面上的颗粒的凹槽，从而使颗粒和 增强了内聚合物基材。

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