公开(公告)号：US20210189471A1

公开(公告)日：2021-06-24

申请号：US16498877

申请日：2018-03-09

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyun-Chul YOON ,  Jae-Ho KIM ,  Yong-Duk HAN ,  Hyeong-Jin CHUN

IPC: C12Q1/6825 ,  G01N21/55 ,  G02B5/126

Abstract: An optical gene biosensor is disclosed. The optical gene biosensor includes a substrate; a molecular beacon anchored to the substrate, wherein the molecular beacon includes an oligonucleotide specifically binding to a target nucleic acid molecule and a first compound bound to a first terminal of the oligonucleotide; an optical marker specifically binding to the first compound, wherein the optical marker is configured to retro-reflect irradiated light; a light source for irradiating the optical marker with light; and a light-receiver for receiving light retro-reflected from the optical marker. The optical gene biosensor may perform accurate quantitative analysis of a target nucleic acid molecule using both non-spectral and spectral light sources.