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公开(公告)号：US11633500B2
公开(公告)日：2023-04-25
申请号：US16852148
申请日：2020-04-17
申请人： AGENSYS, INC.
发明人： Daniel Sousa Pereira , Faisal Hayat Malik , Josh Snyder , Leslie Renee Butterworth , Ssucheng Jeff Hsu , Peng Yang , Claudia Isabel Guevara
摘要： Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09925273B2
公开(公告)日：2018-03-27
申请号：US14447209
申请日：2014-07-30
申请人： AGENSYS, INC.
发明人： Daniel Sousa Pereira , Faisal Hayat Malik , Josh Snyder , Leslie Renee Butterworth , Ssucheng Jeff Hsu , Peng Yang , Claudia Isabel Guevara
IPC分类号： A61K39/395 , A61K47/48 , A61K45/06
CPC分类号： A61K47/6851 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849
摘要： Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US10646583B2
公开(公告)日：2020-05-12
申请号：US15892401
申请日：2018-02-08
申请人： AGENSYS, INC.
发明人： Daniel Sousa Pereira , Faisal Hayat Malik , Josh Snyder , Leslie Renee Butterworth , Ssucheng Jeff Hsu , Peng Yang , Claudia Isabel Guevara
摘要： Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
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