公开(公告)号：US20130276154A1

公开(公告)日：2013-10-17

申请号：US13721618

申请日：2012-12-20

Applicant: Advanced Cell Technology, Inc.

Inventor： Michael West

IPC: C12N5/0735

CPC classification number: C12N5/0606 ,  A01K2217/05 ,  A01K2267/0393 ,  A61K35/12 ,  C12N15/85 ,  C12N2510/00 ,  C12N2517/10

Abstract: Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous MHC allele cell lines are provided. These cells are produced preferably from parthenogenic, IVF, or same-species or cross-species nuclear transfer embryos or by dedifferentiation of somatic cells by cytoplasm transfer. Methods for using these stem cell banks for producing stem and differentiated cells for therapy, especially acute therapies, and for screening for drugs for disease treatment are also provided.

Abstract translation: 提供了可选地可以是转基因的例如由纯合MHC等位基因细胞系组成的干细胞组，优选人的方法。 这些细胞优选地由单性生殖，IVF或相同种类或跨物种核转移胚产生，或通过细胞质转移去体细胞分化。 还提供了使用这些干细胞库来产生干细胞和分化细胞用于治疗，特别是急性治疗以及筛选用于疾病治疗的药物的方法。

公开(公告)号：US10047340B2

公开(公告)日：2018-08-14

申请号：US13721618

申请日：2012-12-20

Applicant: ADVANCED CELL TECHNOLOGY, INC.

Inventor： Michael West

IPC: C12N5/00 ,  C12N5/0735 ,  C12N15/85 ,  A61K35/12

CPC classification number: C12N5/0606 ,  A01K2217/05 ,  A01K2267/0393 ,  A61K35/12 ,  C12N15/85 ,  C12N2510/00 ,  C12N2517/10

Abstract: Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous MHC allele cell lines are provided. These cells are produced preferably from parthenogenic, IVF, or same-species or cross-species nuclear transfer embryos or by dedifferentiation of somatic cells by cytoplasm transfer. Methods for using these stem cell banks for producing stem and differentiated cells for therapy, especially acute therapies, and for screening for drugs for disease treatment are also provided.