公开(公告)号：US20210364494A1

公开(公告)日：2021-11-25

申请号：US16635911

申请日：2018-08-01

Applicant: ACEA BIOSCIENCES, INC.

Inventor： Nan Li ,  Yama Abassi ,  Xiao Xu ,  Xiaobo Wang

IPC: G01N33/483 ,  G01N1/14 ,  G01N27/02

Abstract: A method of assessing cytolysis of cancer cells, the method including: providing a cell substrate impedance monitoring cartridge having a plurality of chambers, each chamber having an electrode array configured for measuring cell-substrate impedance, wherein different chambers are preloaded with different target cells embodied as cancer cells of different lineage, origin or stage; adding effector cells to the plurality chambers for interaction with the target cells, wherein the effector cells are immune cells; monitoring cell-substrate impedance of the plurality of chambers before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedances; and determining effectiveness of effector cell killing of the different target cells by comparing the impedances or impedance-based parameters over time.