公开(公告)号：US20230302114A1

公开(公告)日：2023-09-28

申请号：US17998208

申请日：2021-05-07

申请人： ACADEMIA SINICA

发明人： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC分类号： A61K39/145 ,  C07K14/005 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

摘要： The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20240316179A1

公开(公告)日：2024-09-26

申请号：US18662436

申请日：2024-05-13

申请人： ACADEMIA SINICA

发明人： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

摘要： The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20240100147A1

公开(公告)日：2024-03-28

申请号：US18501578

申请日：2023-11-03

申请人： ACADEMIA SINICA

发明人： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

摘要： The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).