专利检索 ap:("ABWIZ BIO, INC.") AND inv:"Toshiaki MARUYAMA" 第 1 页

1.

发明公开
HUMANIZATION, AFFINITY MATURATION, AND OPTIMIZATION METHODS FOR PROTEINS AND ANTIBODIES 审中-公开

公开(公告)号：US20240352445A1

公开(公告)日：2024-10-24

申请号：US18683502

申请日：2022-08-15

申请人： ABWIZ BIO, INC.

发明人： Toshiaki MARUYAMA , Shigeru CJ Okumura , Kevin ENTZMINGER

IPC分类号： C12N15/10 , C07K16/10 , G01N33/68

CPC分类号： C12N15/1037 , C07K16/1003 , C12N15/1058 , G01N33/6845

摘要： The present disclosure discloses a method for identifying an optimized protein. The method involves constructing and targeting targeted libraries against a target antigen using a first set of selection conditions to select a pool of binders in each library, combining the selected libraries into one or more libraries; and selecting the combined library against the target antigen using a second set of selection conditions to identify at least one protein having an optimized functional profile. An exemplar protein that can be identified with this method is an antibody or a fragment thereof.