公开(公告)号：US20230268026A1

公开(公告)日：2023-08-24

申请号：US18046849

申请日：2022-10-14

Applicant: ABSCI CORPORATION

Inventor： Roberto Spreafico ,  Goran Rakocevic ,  Ariel Schwartz ,  Joshua Meier

IPC: G16B20/30 ,  G06N3/08 ,  G16B20/20 ,  G16B40/20

CPC classification number: G16B20/30 ,  G06N3/08 ,  G16B20/20 ,  G16B40/20

Abstract: A computing system includes a processor and a memory having stored thereon a trained machine-learned model and instructions that, when executed by the one or more processors, cause the computing system to process a biomolecule sequence variant to predict binding characteristics, identify biomolecule sequence variants of interest; and provide the biomolecule sequence variants of interest as output. A computer-implemented method for training a machine learning model to identify biomolecule sequence variants of interest includes generating biomolecule sequence variants, receiving screening data; and training the machine learning model to predict binding characteristics of an input biomolecule sequence variant. A computing system includes a processor; and a non-transitory computer-readable media having stored thereon a machine-learned model trained using training data and instructions that, when executed by the one or more processors, cause the computing system to: process one or more input biomolecule sequence variants; and provide a predicted naturalness characteristics as output.

公开(公告)号：US20250051823A1

公开(公告)日：2025-02-13

申请号：US18723092

申请日：2022-12-13

Applicant: ABSCI CORPORATION

Inventor： Miles Gander ,  Amy E. Doerner ,  Carla Risso ,  Gregory Hannum ,  Ariel Schwartz

IPC: C12P21/02 ,  C12N9/08 ,  C12N15/62 ,  C12N15/70

Abstract: The disclosure provides products and methods for the heterologous expression of proteins in host cells. The provided expression constructs, bacterial cells and methods produce a PnlP-1 accessory protein that increases the yield of a heterologous protein of interest.