公开(公告)号：US10919851B2

公开(公告)日：2021-02-16

申请号：US16320929

申请日：2017-07-28

Applicant: ABAC THERAPEUTICS, S.L

Inventor： Albert Palomer Benet ,  Domingo Gargallo Viola

IPC: C07D207/09 ,  C07D207/46 ,  C07D207/50 ,  C07D211/36 ,  C07D211/40 ,  C07D211/94 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  A61P31/04 ,  A61K31/40 ,  A61K31/4025 ,  A61K45/06

Abstract: 2-Pyrrolidine phenylhydrazides antibacterial agents The present invention relates to 2-pyrrolidine phenylhydrazide compounds of formula (I), which are selective antibacterials specifically against Acinetobacter baumannii. The invention also relates to their therapeutic use as antibacterials, to a process for their preparation and to pharmaceutical compositions containing them.

公开(公告)号：US09840467B2

公开(公告)日：2017-12-12

申请号：US15500333

申请日：2015-07-29

Applicant: ABAC THERAPEUTICS, S.L.

Inventor： Domingo Gargallo Viola ,  Albert Palomer Benet

IPC: C07D211/90 ,  A61K31/4412

CPC classification number: C07D211/90

Abstract: The present invention belongs to the field of antibacterial agents, more specifically to antibacterials for treating Acinetobacter baumannii infections. The invention provides arylhydrazides containing a 2-pyridone moiety, according to formula (I), which show selective antibacterial activity against A. baumannii. The invention also relates to their use as medicaments and specifically as antibacterials for the treatment of A. baumannii infections, as well as to a process for their preparation and to pharmaceutical compositions containing them.