公开(公告)号：US11499166B2

公开(公告)日：2022-11-15

申请号：US17241032

申请日：2021-04-26

Applicant: 4D MOLECULAR THERAPEUTICS INC.

Inventor： Melissa Kotterman ,  Peter Francis ,  Melissa Calton ,  Johnny Gonzales ,  Roxanne Croze ,  Christopher Schmitt

IPC: C12N15/86

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

公开(公告)号：US11807868B2

公开(公告)日：2023-11-07

申请号：US17938641

申请日：2022-10-06

Applicant: 4D MOLECULAR THERAPEUTICS INC.

Inventor： Melissa Kotterman ,  Peter Francis ,  Melissa Calton ,  Johnny Gonzales ,  Roxanne Croze ,  Christopher Schmitt

IPC: C12N15/86 ,  C07K14/005 ,  A61K9/12 ,  A61K9/00 ,  C07K14/47 ,  A61P11/00

CPC classification number: C12N15/86 ,  A61K9/0078 ,  A61K9/12 ,  A61P11/00 ,  C07K14/005 ,  C07K14/4712 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14141 ,  C12N2750/14142 ,  C12N2750/14143 ,  C12N2750/14151

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

公开(公告)号：US20240067987A1

公开(公告)日：2024-02-29

申请号：US18468142

申请日：2023-09-15

Applicant: 4D MOLECULAR THERAPEUTICS INC.

Inventor： Melissa Kotterman ,  Peter Francis ,  Melissa Calton ,  Johnny Gonzales ,  Roxanne Croze ,  Christopher Schmitt

IPC: C12N15/86 ,  A61K9/00 ,  A61K9/12 ,  A61P11/00 ,  C07K14/005 ,  C07K14/47

CPC classification number: C12N15/86 ,  A61K9/0078 ,  A61K9/12 ,  A61P11/00 ,  C07K14/005 ,  C07K14/4712 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14141 ,  C12N2750/14142 ,  C12N2750/14143 ,  C12N2750/14151

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant A.AV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

公开(公告)号：US20230257772A1

公开(公告)日：2023-08-17

申请号：US17938641

申请日：2022-10-06

Applicant: 4D Molecular Therapeutics Inc.

Inventor： Melissa Kotterman ,  Peter Francis ,  Melissa Calton ,  Johnny Gonzales ,  Roxanne Croze ,  Christopher Schmitt

IPC: C12N15/86 ,  C07K14/005 ,  A61K9/12 ,  A61K9/00 ,  C07K14/47 ,  A61P11/00

CPC classification number: C12N15/86 ,  C07K14/005 ,  A61K9/12 ,  A61K9/0078 ,  C07K14/4712 ,  A61P11/00 ,  C12N2750/14141

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.