公开(公告)号：US20240018498A1

公开(公告)日：2024-01-18

申请号：US18463979

申请日：2023-09-08

Applicant: 4D MOLECULAR THERAPEUTICS INC.

Inventor： David H. KIRN ,  Melissa KOTTERMAN ,  Peter FRANCIS ,  David SCHAFFER ,  Paul SZYMANSKI ,  Kevin WHITTLESEY

IPC: C12N9/40 ,  A61K9/00 ,  A61P3/00 ,  C12N15/86 ,  A61K48/00

CPC classification number: C12N9/2465 ,  C12Y302/01022 ,  A61K9/0019 ,  A61P3/00 ,  C12N15/86 ,  A61K48/0066 ,  A61K48/0075 ,  A61K48/0083 ,  C12N2840/00 ,  A61K48/00

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding hum n alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.

公开(公告)号：US20210332341A1

公开(公告)日：2021-10-28

申请号：US17240948

申请日：2021-04-26

Applicant: 4D MOLECULAR THERAPEUTICS INC.

Inventor： David H. KIRN ,  Melissa KOTTERMAN ,  Peter FRANCIS ,  David SCHAFFER ,  Paul SZYMANSKI ,  Kevin WHITTLESEY

IPC: C12N9/40 ,  A61K9/00 ,  C12N15/86 ,  A61P3/00

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human alpha-galactosidase A, vectors, and host cells comprising codon optimized alpha-galactosidase A sequences, and methods of treating disorders such as Fabry disease comprising administering to the subject a codon optimized sequence encoding human alpha-galactosidase A.