公开(公告)号：US20240336593A1

公开(公告)日：2024-10-10

申请号：US18043962

申请日：2021-09-03

Applicant: lnnovStoneTherapeutics Limited

Inventor： Qun Dang ,  Hanyu Yang ,  Pan Li ,  Chunhua Jiang ,  Zhou Yin ,  Jianbin Ma ,  Xiaodan Fu ,  Xin Cai

IPC: C07D401/14 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D513/04

CPC classification number: C07D401/14 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D513/04

Abstract: The present disclosure provides a compound having a novel structure as a PRMT5 inhibitor, a method for preparing the compound, and use thereof in the treatment of a disease mediated by a PRMT5 inhibitor. Experiments have shown that these compounds have a strong inhibitory effect on PRMT5, and can be used as promising candidate compounds for treatment of diseases mediated by PRMT5 inhibitors. In addition, a specific synthetic method is developed in the present disclosure, which has a simple process and convenient operation, and is beneficial to industrial mass production and application.